If you can’t forgive yourself, you think you’re never going to be able to forgive yourself, and you repeat the same behavior.

A lot of times I think people, when they’re doing a movie that’s a family movie, they’re worried about this being too esoteric or too dark or too weird.

I don’t like the sound of my voice or how I look or anything.

I had a small part in ‘Pineapple Express.’

Sometimes you’re working with somebody, and you can tell they’re just waiting to say their line.

I was a production assistant in the post department on ‘The Surreal Life.’ And it’s been reported before that I was an assistant editor on ‘The Surreal Life.’ That is not true.

‘SNL’ is really hard to do when you’re single and living alone. And then it’s pretty tough when you’re married, because you don’t see your spouse.

I work a lot, and it’s kind of like, you meet people, and you just click. It’s not like I’m looking at something and thinking: ‘South Park’ – how do I get on that?’ I...

I was in a sketch group in L.A., and we were playing, like, backyards in Glendale and stuff. It was pretty ugly because we didn’t have any money.

When I met Judd Apatow, he told me I should start writing screenplays. They’d be really bad at first, but the more I did it, the better I’d get.

To be totally honest? I don’t know if I’ll keep doing more impressions. People told me I had a facility for it, and I was like, ‘Okay, I’m the impression guy.’ So you imagine the...

I was never that good on stage with live improv. I was much better on film or writing something and then thinking about it. I was too in my head when I was on stage.

David Sedaris is so good that it makes me mad.

In Tulsa, it was sports or nothing.

Even though it doesn’t look like it, I run. On a treadmill. And I bounce around to all the songs on my iPod – the Pixies, Wagner, Richard and Linda Thompson, even books on tape....

I get migraines a lot. I get them when I’m stressed out. My brain freezes, and I just try to get through that.

I hated pitch meetings. Pitch meetings were my least favorite part of the week. I just gave up. I was so terrible at them.

The first time I ever acted was in ‘The Glass Menagerie’ in high school, and my first line was, ‘I didn’t know Shakespeare had a sister.’

I’m the only one in Tulsa, Oklahoma, that has Final Draft on my computer. Then you show up and go to any coffee shop in L.A., and there are a hundred people your age with...

I have a lot of incomplete short films and incomplete scripts out there.

My first real job, I sold Christmas trees when I was twelve for extra money. I did that until I was fifteen. Then I bagged groceries, and I worked at the first Borders ever in...

I was offered a lot of supporting crazy parts in comedies because that’s all I had done.

When people tell you what doesn’t work, they’re usually right. When they tell you how to fix it, they’re usually wrong.

‘Vanity Fair’ did this grid thing a couple years ago, connecting people who’ve worked together, and I had the most branches on it or whatever, because I’d worked with so-and-so and so-and-so worked with so-and-so,...

My wife and I were on our honeymoon in Turks and Caicos, in the middle of nowhere, and I’m sitting on this deserted beach, and I see one lone person walking along the shore. He...

Every relationship is work.

Jon Ronson makes me laugh. I’ve read all of his books.

I can’t do Twitter or Facebook, mostly because I feel like I’m the type of person who has to regiment the amount of time I spend doing certain things or I’ll just wade in it,...

I learned a lot just watching people perform.

I like watching Kate McKinnon do something – there’s a joy in seeing a new move from somebody and going, ‘Oh, she can do that.’

The first time I met James Franco, he was dressed like James Dean. He was James Dean, literally, filming a biopic.

I’ve seen people who come to work say, ‘No, I’m doing it this way, and that’s that.’ I’m the opposite – I like being out of my element; it’s where I like to live.

I just did this movie with Kristin Wiig called ‘The Skeleton Twins.’ That’s a straight drama. We play estranged twins, and I end up moving in with her and her husband, played by Luke Wilson....

When it comes to comedy, it might be interesting to know why an airplane works, but really? Maybe it’s better not to know why certain things work. Just fly the thing, and if nothing falls...

I would do ‘Superbad,’ and the next offers you would get would all be crazy cop characters or crazy security guards or something.

When you’re at your absolute, most exhausted… That’s when you have to be at the top of your game.

Voices are a good way to get in and out of things. James Carville constantly calls my wife to say I’ll be home late. Mandy Patinkin and Al Pacino call to get me restaurant reservations.

I’m never going to say, ‘Well, I’m never going to do comedy again.’ I love comedies, and it’s what people know me for, so I love doing it… I don’t really think about it in...

Every two months, I would get an email, ‘Skeleton Twins update: still don’t have the money!’

Las Vegas, New Mexico has had a lot of great movies shot there.

I don’t believe in the term ‘guilty pleasure,’ because it implies I should feel ashamed for liking something. A real guilty pleasure would be, I don’t know, taking gratification in some stranger’s ghastly death or...

I remember seeing ‘Spinal Tap’ at a young age and being like, ‘That’s how you perform comedy.’

I like when you are telling a story and fall into an impression.

The nature of ‘SNL’ is that it’s so in-the-moment.

If I get a chance to write a comic book or do a voice in an Adult Swim show, I do it. It’s much more fulfilling to me and I get to work with people...

When I got to ‘Saturday Night Live,’ it was a lot like going from pre-school to Harvard, and it took a long time to figure stuff out.

I remember I could do – I did Bart Simpson once on the bus. I did, like, a really good Bart Simpson voice on the bus, obviously before I hit puberty. And everybody went, ‘Whoa,...

I would say it wasn’t until my fourth season on ‘SNL’ where people or my agent was saying, ‘You’re an actor.’ I never thought of it that way.

When you’re performing, you’re playing to the back row. With acting, you have to be more nuanced.

When I was on ‘SNL,’ I was getting weirdly anxious about being on camera, which I had never really done before. And so my solution was just to not watch my stuff. And then I...