It’s really rare for people to have a successful start-up in this industry without a breakthrough product. I’ll take it a step further. It has to be a radical product. It has to be something...

Over the next 10 years, I expect many more industries to be disrupted by software, with new world-beating Silicon Valley companies doing the disruption in more cases than not.

We have never lived in a time with the opportunity to put a computer in the pocket of 5 billion people.

A lot of things you want to do as part of daily life can now be done over the Internet.

Tech stocks are trading at a 30-year-low when compared to the multiples of industrials (companies). It’s the weirdest bubble when everyone hates everything.

Technology is like water; it wants to find its level. So if you hook up your computer to a billion other computers, it just makes sense that a tremendous share of the resources you want...

Once you understand that everybody’s going to get connected, a lot of things follow from that. If everybody gets the Internet, they end up with a browser, so they look at web pages – but...

There is an enormous market demand for information. It just has to be fulfilled in a way that fits with the technology of our times.

I have yet to take capital losses on any company. Then again, it’s still early.

People are so bad at driving cars that computers don’t have to be that good to be much better. Any time you stand in line at the D.M.V. and look around, you’re like, Oh, my...

There will be certain points of time when everything collides together and reaches critical mass around a new concept or a new thing that ends up being hugely relevant to a high percentage of people...

One of the advantages of moving quickly is if you do something wrong you can change it. What technologies tend to do is they tend to make a lot of mistakes… but then we go...

I don’t waste time being depressed.

When I started Netscape I was brand new out of college and all the aspects of building a business, like balance sheets and hiring people, were new to me.

With lower start-up costs and a vastly expanded market for online services, the result is a global economy that for the first time will be fully digitally wired-the dream of every cyber-visionary of the early...

One of the big first computers was called SAGE, which was a missile defense, the first missile-defense computer, which was, like, one of the first computers in the history of the world which got sold...

More and more major businesses and industries are being run on software and delivered as online services – from movies to agriculture to national defense.

I need more raw experience. I’ve read and watched a lot of things, but I haven’t done a lot of things.

People tend to think of the web as a way to get information or perhaps as a place to carry out ecommerce. But really, the web is about accessing applications. Think of each website as...

In the next 10 years, I expect at least five billion people worldwide to own smartphones, giving every individual with such a phone instant access to the full power of the Internet, every moment of...

China is very entrepreneurial but has no rule of law. Europe has rule of law but isn’t entrepreneurial. Combine rule of law, entrepreneurialism and a generally pro-business policy, and you have Apple.

The smartphone revolution is under-hyped, more people have access to phones than access to running water. We’ve never had anything like this before since the beginning of the planet.

On the back end, software programming tools and Internet-based services make it easy to launch new global software-powered start-ups in many industries – without the need to invest in new infrastructure and train new employees.

We worked personally with a lot of great VCs. They just work incredibly hard at supporting entrepreneurs and their companies.

These days, you have the option of staying home, blogging in your underwear, and not having your words mangled. I think I like the direction things are headed.

Companies in every industry need to assume that a software revolution is coming.

I think 2012 is the year when consumers all around the world start saying no to feature phones and start saying yes to smartphones.

The big advantage that we have as a venture capital firm over a hedge fund or a mutual fund is we have a 13-year lockup on our money. And so enterprise can go in and...

Newspapers with declining circulations can complain all they want about their readers and even say they have no taste. But you will still go out of business over time. A newspaper is not a public...

I think the tech stock, the public market is still completely traumatized by the dotcom crash. I think the investors and reporters and analysts and everybody is determined to not get taken advantage of again,...

I don’t like to not call a spade a spade.

Our combination of great research universities, a pro-risk business culture, deep pools of innovation-seeking equity capital and reliable business and contract law is unprecedented and unparalleled in the world.

I know where I’m putting my money.

Ten to 20 years out, driving your car will be viewed as equivalently immoral as smoking cigarettes around other people is today.

Health care and education, in my view, are next up for fundamental software-based transformation.

I’m really excited about anything that is able to address the really big markets, so anything that’s universally appealing.

If you’re unhappy, you should change what you’re doing.

The joke about SAP has always been, it’s making ’50s German manufacturing methodology, implemented in 1960s software technology, delivered to 1970-style manufacturing organizations, like, it’s really – yeah, the incumbency – they are still the...

Perhaps the single most dramatic example of this phenomenon of software eating a traditional business is the suicide of Borders and corresponding rise of Amazon.

If there’s been a crisis in a market, you don’t tend to have a new crisis in that market until the people who went through the last crisis aren’t in the system anymore.

Qualified software engineers, managers, marketers and salespeople in Silicon Valley can rack up dozens of high-paying, high-upside job offers any time they want, while national unemployment and underemployment is sky high.

There’s always more demands than there’s time to meet them, so it’s constantly a matter of trying to balance them.

Almost every dot-com idea from 1999 that failed will succeed.

You are cruising along, and then technology changes. You have to adapt.

I’ve been a customer of the top venture capital firms, so I know exactly what they do and don’t do.

In the startup world, you’re either a genius or an idiot. You’re never just an ordinary guy trying to get through the day.

It’s hard to do that with people who think emotionally. A lot of people think in terms of people, emotions, and feelings. That’s more complicated. Engineering mentality makes it, in theory, a little easier.

A very large percentage of economic activity is shifting online and it makes sense that there are more services that are going to charge. It also means there are going to be more people willing...

There’s no such thing as median income; there’s a curve, and it really matters what side of the curve you’re on. There’s no such thing as the middle class. It’s absolutely vanishing.

Where I grew up, we had the three TV networks, maybe two radio stations, no cable TV. We still had a long-distance party line in our neighborhood, so you could listen to all your neighbors’...