One should never give up on hope. Unless that’s the name of the girl who cheated on you in which case, yeah, give her up.

Really, Mr. Collins,’ cried Elizabeth with some warmth, ‘you puzzle me exceedingly. If what I have hitherto said can appear to you in the form of encouragement, I know not how to express my refusal...

Chemistry is great, but eventually your relationship moves out of the laboratory.