This is a novel study, and although the results seem disappointing to some, we see points of encouragement.

The long-term legacy will be one of encouraging this research area. We need to find that intervention that will make a big difference.

The changes that we need to make are best if they’re lifetime changes.

We don’t see any hint of a reduction in (colorectal cancer). For heart disease, we saw only a tiny reduction in the bad cholesterol.

The bottom line is that changing to a low-fat diet may reduce breast cancer risk, especially among women who have a relatively high-fat diet to begin with, but we don’t view our data as strong...

Even though the data are not as precise as we would like, they do bring some fresh and important data to the table that hadn’t existed before.

If we had achieved an even higher adherence rate, I believe the study’s results would have been more dramatic.

Women that are already eating a low-fat diet have every reason to continue.

I think women who are currently following a low-fat diet should be encouraged to do so. We didn’t see any unfavorable effects. For women who are at high risk for breast cancer, they should talk...