It may turn out that future antidepressants could target this 5-HT receptor, and probably some additional 5-HT receptors, but not necessarily all 5-HT receptors. Hopefully, such antidepressants will have fewer side effects.

We have shown that a gene (or protein) called p11 is involved in the multiple complex changes that underlie depression.

We have shown that a gene called p11 is involved in the multiple complex changes that underlie depression. Our findings demonstrate that patients with depression, and mice that model this disease, have decreased levels of...

In addition to exploring ways to increase p11 in depressed patients, it may also be possible to develop peptide-based compounds that can mimic the action of p11 to achieve a new class of anti-depressant compounds.