Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied...

We are only chance visitants to this jungle of blind mutations. The natural world existed when we did not, and it will continue to exist long after we are gone. The supernatural crept into life...

Although random mutations influenced the course of evolution, their influence was mainly by loss, alteration, and refinement… Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear....

The secrets of evolution are death and time—the deaths of enormous numbers of lifeforms that were imperfectly adapted to the environment; and time for a long succession of small mutations.

New mutations don’t create new species; they create offspring that are impaired.